Lornoxicam is and Diclofenac sodium is analgesic, antipyretic drugs both are NSAID class. The combination of this two drug is used for the treatment of rheumatoid arthritis. Two new ,simple,accurate and precise uv spectrophotometric methods have been developed amd validated for the simultaneous determination of Lornoxicam (LOR) and Diclofenac sodium (DIC) in their combine dosage forms. The first derivative spectroscopy method (Method A) in which first derivative amplitudes were measured at selected wavelengths. The amplitudes at 251 nm and 263 nm in the first derivative spectra were selected to determine LOR and DIC, respectively. Beer’s law is obeyed in the concentration ranges of 4-24 and 3-18 μg/ml for LOR and DIC respectively in methanol for both the methods. The second method is Q-absorbance method. For Q-absorbance method the absorbances of the standard solutions were taken at two wavelengths 281.2 nm (λmax of lornoxicam) and 260.6 nm (Isobestic point), in methanol. Beer’s law is obeyed in the concentration ranges of 4-40 and 3-18 μg/ml for LOR and DIC respectively in methanol for both the methods. Both methods were validated statistically and recovery studies carry out.The suitability of this method for the quantitative determination of Lornoxicam and Diclofenac sodium was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of Lornoxicam and Diclofenac sodium in combination. The results of analysis have been validated statistically and by recovery studies.The validation study is statistically significant as all statistical parameter are within the acceptance range (% RSD<2.0 and S.D.<2.0) for both accuracy and precision.
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